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Shh Rabbit mAb
商品貨號: PRM8801
適 應(yīng) 性: 人,小鼠,大鼠
WB IHC IF ELISA IP
¥800元
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商品描述
  • 發(fā)貨日期: 現(xiàn)貨
  • 靶點-Target: Shh
  • 反應(yīng)性-Reactivity: 人,小鼠,大鼠
  • 應(yīng)用-Applications: WB,IHC,IF,IP,ELISA
  • MW(Calculated): 50kD
  • MW(Observed): 27kD
  • 宿主物種-Host Species: Rabbit
  • 同種型-Isotype: IgG, Kappa
  • 偶聯(lián)-Conjugate: Unmodified
  • 推薦稀釋比: IHC 1:200-1:1000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;
  • 組成: PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
  • 純化工藝: Protein A
  • 儲存: -15°C to -25°C/1 year(Do not lower than -25°C)
  • 克隆性: Monoclonal
  • 克隆號: PT0962R
  • 特異性: Endogenous
  • 基因名稱: SHH
  • 蛋白名稱: Shh
  • 別名: Sonic hedgehog protein;SHH;HHG-1;[Cleaved into: Sonic hedgehog protein N-product;Sonic hedgehog protein C-product]
  • Organism-1: Human
  • 基因ID-1: 6469
  • SwissProt-1: Q15465
  • 背景: This gene encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a d
  • 細(xì)胞定位: Endoplasmic reticulum membrane . Golgi apparatus membrane . Co-localizes with HHAT in the ER and Golgi membrane. .; [Sonic hedgehog protein N-product]: Cell membrane ; Lipid-anchor . The dual-lipidated sonic hedgehog protein N-product (ShhNp) is firmly tethered to the cell membrane where it forms multimers (PubMed:24522195). Further solubilization and release from the cell surface seem to be achieved through different mechanisms, including the interaction with DISP1 and SCUBE2, movement by lipoprotein particles, transport by cellular extensions called cytonemes or by the proteolytic removal of both terminal lipidated peptides (PubMed:26875496, PubMed:24522195). .
Shh Rabbit mAb
Catalog No PRM8801
Product information
  • 發(fā)貨日期: 現(xiàn)貨
  • 靶點-Target: Shh
  • 反應(yīng)性-Reactivity: 人,小鼠,大鼠
  • 應(yīng)用-Applications: WB,IHC,IF,IP,ELISA
  • MW(Calculated): 50kD
  • MW(Observed): 27kD
  • 宿主物種-Host Species: Rabbit
  • 同種型-Isotype: IgG, Kappa
  • 偶聯(lián)-Conjugate: Unmodified
  • 推薦稀釋比: IHC 1:200-1:1000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;
  • 組成: PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
  • 純化工藝: Protein A
  • 儲存: -15°C to -25°C/1 year(Do not lower than -25°C)
  • 克隆性: Monoclonal
  • 克隆號: PT0962R
  • 特異性: Endogenous
  • 基因名稱: SHH
  • 蛋白名稱: Shh
  • 別名: Sonic hedgehog protein;SHH;HHG-1;[Cleaved into: Sonic hedgehog protein N-product;Sonic hedgehog protein C-product]
  • Organism-1: Human
  • 基因ID-1: 6469
  • SwissProt-1: Q15465
  • 背景: This gene encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a d
  • 細(xì)胞定位: Endoplasmic reticulum membrane . Golgi apparatus membrane . Co-localizes with HHAT in the ER and Golgi membrane. .; [Sonic hedgehog protein N-product]: Cell membrane ; Lipid-anchor . The dual-lipidated sonic hedgehog protein N-product (ShhNp) is firmly tethered to the cell membrane where it forms multimers (PubMed:24522195). Further solubilization and release from the cell surface seem to be achieved through different mechanisms, including the interaction with DISP1 and SCUBE2, movement by lipoprotein particles, transport by cellular extensions called cytonemes or by the proteolytic removal of both terminal lipidated peptides (PubMed:26875496, PubMed:24522195). .
  • Hunan UPT Biotechnology Co.,Ltd
    Website:www.hyjdss.com Servive hotline :4006916686
    E-mail:service@uptbio.com
    Address:
    Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.
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