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MMP9 Rabbit mAb
商品貨號(hào): PRM8626
適 應(yīng) 性: 小鼠,大鼠,
WB IHC IF ELISA IP
¥7000元
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商品描述
  • 發(fā)貨日期: 現(xiàn)貨
  • 靶點(diǎn)-Target: MMP-9
  • 反應(yīng)性-Reactivity: 小鼠,大鼠,
  • 應(yīng)用-Applications: WB,IHC,IF,IP,ELISA
  • 宿主物種-Host Species: Rabbit
  • 同種型-Isotype: IgG,Kappa
  • 偶聯(lián)-Conjugate: Unmodified
  • 推薦稀釋比: IHC 1:200-1000;WB 1:500-5000;IF 1:200-1000;ELISA 1:5000-20000;IP 1:50-200
  • 組成: PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
  • 純化工藝: Protein A
  • 儲(chǔ)存: -15°C to -25°C/1 year(Do not lower than -25°C)
  • 克隆性: Monoclonal
  • 克隆號(hào): PT0731R
  • 特異性: Endogenous
  • 基因名稱: MMP9 CLG4B
  • 蛋白名稱: MMP9 (Cleaved-Met94)
  • 別名: Matrix metalloproteinase-9;MMP-9;92 kDa gelatinase;92 kDa type IV collagenase;Gelatinase B;GELB;[Cleaved into: 67 kDa matrix metalloproteinase-9;82 kDa matrix metalloproteinase-9]
  • Organism-1: Human
  • 基因ID-1: 4318
  • SwissProt-1: P14780
  • Organism-2: Mouse
  • 基因ID-2: 17395
  • SwissProt-2: P41245
  • Organism-3: Rat
  • 基因ID-3: 81687
  • SwissProt-3: P50282
  • 背景: catalytic activity:Cleavage of gelatin types I and V and collagen types IV and V.,cofactor:Binds 2 zinc ions per subunit.,cofactor:Binds 3 calcium ions per subunit.,disease:Defects in MMP9 may be a cause of susceptibility to lumbar disk herniation (LDH) [MIM:603932]. LDH is the predominant cause of low-back pain and unilateral leg pain.,domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,enzyme regulation:Inhibited by histatin-3 1/24 (histatin-5).,function:May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide.,induction:Activated by 4-aminophenylmercuric acetate and phorbol ester.,miscellaneous:In the arthritis patient this enzyme might contribute to the pathogenesis of joint destruction and might constitute a useful marker of disease status.,PTM:N- and O-glycosylated.,PTM:Processing of the precursor yields different active forms of 64, 67 and 82 kDa. Sequentially processing by MMP3 yields the 82 kDa matrix metalloproteinase-9.,similarity:Belongs to the peptidase M10A family.,similarity:Contains 3 fibronectin type-II domains.,similarity:Contains 4 hemopexin-like domains.,subunit:Exists as monomer, disulfide-linked homodimer, and as a heterodimer with a 25 kDa protein. Macrophages and transformed cell lines produce only the monomeric form.,tissue specificity:Produced by normal alveolar macrophages and granulocytes.,
  • 細(xì)胞定位: Membranous
MMP9 Rabbit mAb
Catalog No PRM8626
Product information
  • 發(fā)貨日期: 現(xiàn)貨
  • 靶點(diǎn)-Target: MMP-9
  • 反應(yīng)性-Reactivity: 小鼠,大鼠,
  • 應(yīng)用-Applications: WB,IHC,IF,IP,ELISA
  • 宿主物種-Host Species: Rabbit
  • 同種型-Isotype: IgG,Kappa
  • 偶聯(lián)-Conjugate: Unmodified
  • 推薦稀釋比: IHC 1:200-1000;WB 1:500-5000;IF 1:200-1000;ELISA 1:5000-20000;IP 1:50-200
  • 組成: PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
  • 純化工藝: Protein A
  • 儲(chǔ)存: -15°C to -25°C/1 year(Do not lower than -25°C)
  • 克隆性: Monoclonal
  • 克隆號(hào): PT0731R
  • 特異性: Endogenous
  • 基因名稱: MMP9 CLG4B
  • 蛋白名稱: MMP9 (Cleaved-Met94)
  • 別名: Matrix metalloproteinase-9;MMP-9;92 kDa gelatinase;92 kDa type IV collagenase;Gelatinase B;GELB;[Cleaved into: 67 kDa matrix metalloproteinase-9;82 kDa matrix metalloproteinase-9]
  • Organism-1: Human
  • 基因ID-1: 4318
  • SwissProt-1: P14780
  • Organism-2: Mouse
  • 基因ID-2: 17395
  • SwissProt-2: P41245
  • Organism-3: Rat
  • 基因ID-3: 81687
  • SwissProt-3: P50282
  • 背景: catalytic activity:Cleavage of gelatin types I and V and collagen types IV and V.,cofactor:Binds 2 zinc ions per subunit.,cofactor:Binds 3 calcium ions per subunit.,disease:Defects in MMP9 may be a cause of susceptibility to lumbar disk herniation (LDH) [MIM:603932]. LDH is the predominant cause of low-back pain and unilateral leg pain.,domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,enzyme regulation:Inhibited by histatin-3 1/24 (histatin-5).,function:May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide.,induction:Activated by 4-aminophenylmercuric acetate and phorbol ester.,miscellaneous:In the arthritis patient this enzyme might contribute to the pathogenesis of joint destruction and might constitute a useful marker of disease status.,PTM:N- and O-glycosylated.,PTM:Processing of the precursor yields different active forms of 64, 67 and 82 kDa. Sequentially processing by MMP3 yields the 82 kDa matrix metalloproteinase-9.,similarity:Belongs to the peptidase M10A family.,similarity:Contains 3 fibronectin type-II domains.,similarity:Contains 4 hemopexin-like domains.,subunit:Exists as monomer, disulfide-linked homodimer, and as a heterodimer with a 25 kDa protein. Macrophages and transformed cell lines produce only the monomeric form.,tissue specificity:Produced by normal alveolar macrophages and granulocytes.,
  • 細(xì)胞定位: Membranous
  • Hunan UPT Biotechnology Co.,Ltd
    Website:www.hyjdss.com Servive hotline :4006916686
    E-mail:service@uptbio.com
    Address:
    Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.
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