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FGFR1 Rabbit mAb
商品貨號： PRM8609
適 應(yīng) 性： 人,
WB IHC IF ELISA IP
￥800元
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商品描述
  • 發(fā)貨日期： 現(xiàn)貨
  • 靶點-Target： FGF Receptor 1
  • 反應(yīng)性-Reactivity： 人,
  • 應(yīng)用-Applications： WB,IHC,IF,IP,ELISA
  • MW(Calculated)： 91kD
  • MW(Observed)： 145kD
  • 宿主物種-Host Species： Rabbit
  • 同種型-Isotype： IgG,Kappa
  • 偶聯(lián)-Conjugate： Unmodified
  • 推薦稀釋比： IHC 1:100-200;WB 1:500-2000;IF 1:200-1000;ELISA 1:5000-20000;IP 1:50-200
  • 組成： PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
  • 純化工藝： Protein A
  • 儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 克隆性： Monoclonal
  • 克隆號： PT0207R
  • 特異性： Endogenous
  • 基因名稱： FGFR1 BFGFR CEK FGFBR FLG FLT2 HBGFR
  • 蛋白名稱： Fibroblast growth factor receptor 1
  • 別名： FGFR1;BFGFR;CEK;FGFBR;FLG;FLT2;HBGFR;Fibroblast growth factor receptor 1;FGFR-1;Basic fibroblast growth factor receptor 1;BFGFR;bFGF-R-1;Fms-like tyrosine kinase 2;FLT-2;N-sam;Proto-oncogene c-Fgr;CD antigen CD331
  • Organism-1： Human
  • 基因ID-1： 2260
  • SwissProt-1： P11362
  • Organism-2： Mouse
  • 基因ID-2： 14182
  • SwissProt-2： P16092
  • Organism-3： Rat
  • 基因ID-3： 79114
  • SwissProt-3： Q04589
  • 背景： The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
  • 細胞定位： Cell membrane; Single-pass type I membrane protein. Nucleus. Cytoplasm, cytosol. Cytoplasmic vesicle. After ligand binding, both receptor and ligand are rapidly internalized. Can translocate to the nucleus after internalization, or by translocation from the endoplasmic reticulum or Golgi apparatus to the cytosol, and from there to the nucleus.
FGFR1 Rabbit mAb
Catalog No PRM8609
Product information
  • 發(fā)貨日期： 現(xiàn)貨
  • 靶點-Target： FGF Receptor 1
  • 反應(yīng)性-Reactivity： 人,
  • 應(yīng)用-Applications： WB,IHC,IF,IP,ELISA
  • MW(Calculated)： 91kD
  • MW(Observed)： 145kD
  • 宿主物種-Host Species： Rabbit
  • 同種型-Isotype： IgG,Kappa
  • 偶聯(lián)-Conjugate： Unmodified
  • 推薦稀釋比： IHC 1:100-200;WB 1:500-2000;IF 1:200-1000;ELISA 1:5000-20000;IP 1:50-200
  • 組成： PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
  • 純化工藝： Protein A
  • 儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 克隆性： Monoclonal
  • 克隆號： PT0207R
  • 特異性： Endogenous
  • 基因名稱： FGFR1 BFGFR CEK FGFBR FLG FLT2 HBGFR
  • 蛋白名稱： Fibroblast growth factor receptor 1
  • 別名： FGFR1;BFGFR;CEK;FGFBR;FLG;FLT2;HBGFR;Fibroblast growth factor receptor 1;FGFR-1;Basic fibroblast growth factor receptor 1;BFGFR;bFGF-R-1;Fms-like tyrosine kinase 2;FLT-2;N-sam;Proto-oncogene c-Fgr;CD antigen CD331
  • Organism-1： Human
  • 基因ID-1： 2260
  • SwissProt-1： P11362
  • Organism-2： Mouse
  • 基因ID-2： 14182
  • SwissProt-2： P16092
  • Organism-3： Rat
  • 基因ID-3： 79114
  • SwissProt-3： Q04589
  • 背景： The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
  • 細胞定位： Cell membrane; Single-pass type I membrane protein. Nucleus. Cytoplasm, cytosol. Cytoplasmic vesicle. After ligand binding, both receptor and ligand are rapidly internalized. Can translocate to the nucleus after internalization, or by translocation from the endoplasmic reticulum or Golgi apparatus to the cytosol, and from there to the nucleus.
    • Hunan UPT Biotechnology Co.,Ltd
    Website：www.hyjdss.com Servive hotline :4006916686
    E-mail：service@uptbio.com
    Address：
    Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.
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