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PERK Monoclonal Antibody
商品貨號： PLA004987
適 應(yīng) 性： 人
WB ELISA
￥600元
規(guī)格：
在線咨詢
MSDS
說明書
商品描述
  • 發(fā)貨日期： 7
  • 基因名稱： EIF2AK3
  • 蛋白名稱： Eukaryotic translation initiation factor 2-alpha kinase 3
  • Human_gene_id： 9451
  • Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9451
  • Human_swiss_prot_no： Q9NZJ5
  • Human_swiss_link： http://www.uniprot.org/uniprotkb/Q9NZJ5/entry
  • Mouse_swiss_prot_no： Q9Z2B5
  • Mouse_swiss_link： http://www.uniprot.org/uniprot/Q9Z2B5
  • 特異性： PERK Monoclonal Antibody detects endogenous levels of PERK protein.
  • 組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 來源： Monoclonal, Mouse
  • 稀釋： WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
  • 純化工藝： Affinity purification
  • 儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 說明書： 1
  • Msds： MSDS_Antibody.pdf
  • 其他名稱： EIF2AK3; PEK; PERK; Eukaryotic translation initiation factor 2-alpha kinase 3; PRKR-like endoplasmic reticulum kinase; Pancreatic eIF2-alpha kinase; HsPEK
  • 信號通路： Alzheimer's disease;
  • 功能： catalytic activity:ATP + a protein = ADP + a phosphoprotein.,disease:Defects in EIF2AK3 are the cause of Wolcott-Rallison syndrome (WRS) [MIM:226980]; also known as multiple epiphyseal dysplasia with early-onset diabetes mellitus. WRS is a rare autosomal recessive disorder, characterized by permanent neonatal or early infancy insulin-dependent diabetes and, at a later age, epiphyseal dysplasia, osteoporosis, growth retardation and other multisystem manifestations, such as hepatic and renal dysfunctions, mental retardation and cardiovascular abnormalities.,domain:The lumenal domain senses perturbations in protein folding in the ER, probably through reversible interaction with HSPA5/BIP.,enzyme regulation:Perturbation in protein folding in the endoplasmic reticulum (ER) promotes reversible dissociation from HSPA5/BIP and oligomerization, resulting in transautophosphorylation and kinase activity induction.,function:Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin D1.,induction:By ER stress.,PTM:Autophosphorylated.,PTM:N-glycosylated.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Forms dimers with HSPA5/BIP in resting cells. Oligomerizes in ER-stressed cells. Interacts with DNAJC3.,tissue specificity:Ubiquitous. A high level expression is seen in secretory tissues.,
  • 相關(guān)產(chǎn)品： YT6126,YT3667,YT3666,YP1055,KA4229C
  • 細胞定位： Endoplasmic reticulum membrane; Single-pass type I membrane protein.
  • 組織表達： Ubiquitous. A high level expression is seen in secretory tissues.
  • 科研貨號： PLA004987
PERK Monoclonal Antibody
Catalog No PLA004987
Product information
  • 發(fā)貨日期： 7
  • 基因名稱： EIF2AK3
  • 蛋白名稱： Eukaryotic translation initiation factor 2-alpha kinase 3
  • Human_gene_id： 9451
  • Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9451
  • Human_swiss_prot_no： Q9NZJ5
  • Human_swiss_link： http://www.uniprot.org/uniprotkb/Q9NZJ5/entry
  • Mouse_swiss_prot_no： Q9Z2B5
  • Mouse_swiss_link： http://www.uniprot.org/uniprot/Q9Z2B5
  • 特異性： PERK Monoclonal Antibody detects endogenous levels of PERK protein.
  • 組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 來源： Monoclonal, Mouse
  • 稀釋： WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
  • 純化工藝： Affinity purification
  • 儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 說明書： 1
  • Msds： MSDS_Antibody.pdf
  • 其他名稱： EIF2AK3; PEK; PERK; Eukaryotic translation initiation factor 2-alpha kinase 3; PRKR-like endoplasmic reticulum kinase; Pancreatic eIF2-alpha kinase; HsPEK
  • 信號通路： Alzheimer's disease;
  • 功能： catalytic activity:ATP + a protein = ADP + a phosphoprotein.,disease:Defects in EIF2AK3 are the cause of Wolcott-Rallison syndrome (WRS) [MIM:226980]; also known as multiple epiphyseal dysplasia with early-onset diabetes mellitus. WRS is a rare autosomal recessive disorder, characterized by permanent neonatal or early infancy insulin-dependent diabetes and, at a later age, epiphyseal dysplasia, osteoporosis, growth retardation and other multisystem manifestations, such as hepatic and renal dysfunctions, mental retardation and cardiovascular abnormalities.,domain:The lumenal domain senses perturbations in protein folding in the ER, probably through reversible interaction with HSPA5/BIP.,enzyme regulation:Perturbation in protein folding in the endoplasmic reticulum (ER) promotes reversible dissociation from HSPA5/BIP and oligomerization, resulting in transautophosphorylation and kinase activity induction.,function:Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin D1.,induction:By ER stress.,PTM:Autophosphorylated.,PTM:N-glycosylated.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Forms dimers with HSPA5/BIP in resting cells. Oligomerizes in ER-stressed cells. Interacts with DNAJC3.,tissue specificity:Ubiquitous. A high level expression is seen in secretory tissues.,
  • 相關(guān)產(chǎn)品： YT6126,YT3667,YT3666,YP1055,KA4229C
  • 細胞定位： Endoplasmic reticulum membrane; Single-pass type I membrane protein.
  • 組織表達： Ubiquitous. A high level expression is seen in secretory tissues.
  • 科研貨號： PLA004987
    • Hunan UPT Biotechnology Co.,Ltd
    Website：www.hyjdss.com Servive hotline :4006916686
    E-mail：service@uptbio.com
    Address：
    Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.
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