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首頁 > 抗體 > 一抗 > 其它 > PDGFR-β Monoclonal Antibody
PDGFR-β Monoclonal Antibody
商品貨號(hào)： PLA004983
適 應(yīng) 性： 人,小鼠
WB ELISA
￥600元
規(guī)格：
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MSDS
說明書
商品描述
  • 發(fā)貨日期： 7
  • 基因名稱： PDGFRB
  • 蛋白名稱： Beta-type platelet-derived growth factor receptor
  • Human_gene_id： 5159
  • Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5159
  • Human_swiss_prot_no： P09619
  • Human_swiss_link： http://www.uniprot.org/uniprotkb/P09619/entry
  • Mouse_gene_id： 18596
  • Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=18596
  • Mouse_swiss_prot_no： P05622
  • Mouse_swiss_link： http://www.uniprot.org/uniprot/P05622
  • 特異性： PDGFR-β Monoclonal Antibody detects endogenous levels of PDGFR-β protein.
  • 組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 來源： Monoclonal, Mouse
  • 稀釋： WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
  • 純化工藝： Affinity purification
  • 儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 說明書： 1
  • Msds： MSDS_Antibody.pdf
  • 其他名稱： PDGFRB; PDGFR; PDGFR1; Platelet-derived growth factor receptor beta; PDGF-R-beta; PDGFR-beta; Beta platelet-derived growth factor receptor; Beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; Platelet-deri
  • 實(shí)測(cè)條帶： 135-180kD
  • 信號(hào)通路： MAPK_ERK_Growth;MAPK_G_Protein;Calcium;Cytokine-cytokine receptor interaction;Focal adhesion;Gap junction;Regulates Actin and Cytoskeleton;Pathways in cancer;Colorectal cancer;Glioma;Prostate cancer;Melanoma;
  • 功能： catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,disease:A chromosomal aberration involving PDGFRB is a cause in many instances of chronic myeloproliferative disorder with eosinophilia (MPE) [MIM:131440]. Translocation t(5;12) with ETV6 on chromosome 12 creating an PDGFRB-ETV6 fusion protein.,disease:A chromosomal aberration involving PDGFRB is found in a form of chronic myelomonocytic leukemia (CMML). Translocation t(5;12)(q33;p13) with EVT6/TEL. It is characterized by abnormal clonal myeloid proliferation and by progression to acute myelogenous leukemia (AML).,disease:A chromosomal aberration involving PDGFRB may be a cause of acute myelogenous leukemia. Translocation t(5;14)(q33;q32) with TRIP11. The fusion protein may be involved in clonal evolution of leukemia and eosinophilia.,disease:A chromosomal aberration involving PDGFRB may be a cause of juvenile myelomonocytic leukemia. Translocation t(5;17)(q33;p11.2) with SPECC1.,disease:A chromosomal aberration involving PDGFRB may be the cause of a myeloproliferative disorder (MBD) associated with eosinophilia. Translocation t(1;5)(q23;q33) that forms a PDE4DIP-PDGFRB fusion protein.,function:Receptor that binds specifically to PDGFB and PDGFD and has a tyrosine-protein kinase activity. Phosphorylates Tyr residues at the C-terminus of PTPN11 creating a binding site for the SH2 domain of GRB2.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 5 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Homodimer, and heterodimer with PDGFRA. Interacts with APS. The autophosphorylated form interacts directly with SHB and with PIK3C2B, maybe indirectly.,
  • 相關(guān)產(chǎn)品： YT5011,YT3640,YT3639,YT3638,YT3637,YP1123,YP0994,YP0742,YP0431,KA4226C,KA1469C
  • 細(xì)胞定位： Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle. Lysosome lumen. After ligand binding, the autophosphorylated receptor is ubiquitinated and internalized, leading to its degradation.
  • 組織表達(dá)： Brain,Spleen,
  • 科研貨號(hào)： PLA004983
PDGFR-β Monoclonal Antibody
Catalog No PLA004983
Product information
  • 發(fā)貨日期： 7
  • 基因名稱： PDGFRB
  • 蛋白名稱： Beta-type platelet-derived growth factor receptor
  • Human_gene_id： 5159
  • Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5159
  • Human_swiss_prot_no： P09619
  • Human_swiss_link： http://www.uniprot.org/uniprotkb/P09619/entry
  • Mouse_gene_id： 18596
  • Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=18596
  • Mouse_swiss_prot_no： P05622
  • Mouse_swiss_link： http://www.uniprot.org/uniprot/P05622
  • 特異性： PDGFR-β Monoclonal Antibody detects endogenous levels of PDGFR-β protein.
  • 組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 來源： Monoclonal, Mouse
  • 稀釋： WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
  • 純化工藝： Affinity purification
  • 儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 說明書： 1
  • Msds： MSDS_Antibody.pdf
  • 其他名稱： PDGFRB; PDGFR; PDGFR1; Platelet-derived growth factor receptor beta; PDGF-R-beta; PDGFR-beta; Beta platelet-derived growth factor receptor; Beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; Platelet-deri
  • 實(shí)測(cè)條帶： 135-180kD
  • 信號(hào)通路： MAPK_ERK_Growth;MAPK_G_Protein;Calcium;Cytokine-cytokine receptor interaction;Focal adhesion;Gap junction;Regulates Actin and Cytoskeleton;Pathways in cancer;Colorectal cancer;Glioma;Prostate cancer;Melanoma;
  • 功能： catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,disease:A chromosomal aberration involving PDGFRB is a cause in many instances of chronic myeloproliferative disorder with eosinophilia (MPE) [MIM:131440]. Translocation t(5;12) with ETV6 on chromosome 12 creating an PDGFRB-ETV6 fusion protein.,disease:A chromosomal aberration involving PDGFRB is found in a form of chronic myelomonocytic leukemia (CMML). Translocation t(5;12)(q33;p13) with EVT6/TEL. It is characterized by abnormal clonal myeloid proliferation and by progression to acute myelogenous leukemia (AML).,disease:A chromosomal aberration involving PDGFRB may be a cause of acute myelogenous leukemia. Translocation t(5;14)(q33;q32) with TRIP11. The fusion protein may be involved in clonal evolution of leukemia and eosinophilia.,disease:A chromosomal aberration involving PDGFRB may be a cause of juvenile myelomonocytic leukemia. Translocation t(5;17)(q33;p11.2) with SPECC1.,disease:A chromosomal aberration involving PDGFRB may be the cause of a myeloproliferative disorder (MBD) associated with eosinophilia. Translocation t(1;5)(q23;q33) that forms a PDE4DIP-PDGFRB fusion protein.,function:Receptor that binds specifically to PDGFB and PDGFD and has a tyrosine-protein kinase activity. Phosphorylates Tyr residues at the C-terminus of PTPN11 creating a binding site for the SH2 domain of GRB2.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 5 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Homodimer, and heterodimer with PDGFRA. Interacts with APS. The autophosphorylated form interacts directly with SHB and with PIK3C2B, maybe indirectly.,
  • 相關(guān)產(chǎn)品： YT5011,YT3640,YT3639,YT3638,YT3637,YP1123,YP0994,YP0742,YP0431,KA4226C,KA1469C
  • 細(xì)胞定位： Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle. Lysosome lumen. After ligand binding, the autophosphorylated receptor is ubiquitinated and internalized, leading to its degradation.
  • 組織表達(dá)： Brain,Spleen,
  • 科研貨號(hào)： PLA004983
    • Hunan UPT Biotechnology Co.,Ltd
    Website：www.hyjdss.com Servive hotline :4006916686
    E-mail：service@uptbio.com
    Address：
    Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.
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