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MTHFR Monoclonal Antibody
商品貨號： PLA004943
適 應 性： 人,大鼠
WB IHC IF ELISA
￥600元
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MSDS
說明書
商品描述
  • 發(fā)貨日期： 7
  • 基因名稱： MTHFR
  • 蛋白名稱： Methylenetetrahydrofolate reductase
  • Human_gene_id： 4524
  • Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4524
  • Human_swiss_prot_no： P42898
  • Human_swiss_link： http://www.uniprot.org/uniprotkb/P42898/entry
  • Mouse_swiss_prot_no： Q9WU20
  • Mouse_swiss_link： http://www.uniprot.org/uniprot/Q9WU20
  • 特異性： MTHFR Monoclonal Antibody detects endogenous levels of MTHFR protein.
  • 組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 來源： Monoclonal, Mouse
  • 稀釋： WB 1:500 - 1:2000. IHC 1:200 - 1:1000. ELISA: 1:10000.. IF 1:50-200
  • 純化工藝： Affinity purification
  • 儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 說明書： 1
  • Msds： MSDS_Antibody.pdf
  • 其他名稱： MTHFR; Methylenetetrahydrofolate reductase
  • 信號通路： One carbon pool by folate;Methane metabolism;
  • 功能： catalytic activity:5-methyltetrahydrofolate + NAD(P)(+) = 5,10-methylenetetrahydrofolate + NAD(P)H.,cofactor:FAD.,disease:Defects in MTHFR are the cause of methylenetetrahydrofolate reductase deficiency (MTHFRD) [MIM:236250]. MTHFRD is autosomal recessive disorder with a wide range of features including homocysteinuria, homocysteinemia [MIM:603174], developmental delay, severe mental retardation, perinatal death, psychiatric disturbances, and later-onset neurodegenerative disorders.,disease:Defects in MTHFR may be a cause of susceptibility to folate-sensitive neural tube defects (folate-sensitive NTD) [MIM:601634]. The most common NTDs are open spina bifida (myelomeningocele) and anencephaly.,disease:Defects in MTHFR may be a cause of susceptibility to ischemic stroke [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.,enzyme regulation:Allosterically regulated by S-adenosylmethionine.,function:Catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine.,online information:Methylenetetrahydrofolate reductase entry,online information:The Singapore human mutation and polymorphism database,pathway:One-carbon metabolism; tetrahydrofolate pathway.,polymorphism:Genetic variation in MTHFR influences susceptibility to occlusive vascular disease, neural tube defects (NTD), colon cancer and acute leukemia.,similarity:Belongs to the methylenetetrahydrofolate reductase family.,subunit:Homodimer.,
  • 相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
  • 細胞定位： cytosol,synapse,
  • 組織表達： Brain,Liver,Lung,
  • 科研貨號： PLA004943
MTHFR Monoclonal Antibody
Catalog No PLA004943
Product information
  • 發(fā)貨日期： 7
  • 基因名稱： MTHFR
  • 蛋白名稱： Methylenetetrahydrofolate reductase
  • Human_gene_id： 4524
  • Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4524
  • Human_swiss_prot_no： P42898
  • Human_swiss_link： http://www.uniprot.org/uniprotkb/P42898/entry
  • Mouse_swiss_prot_no： Q9WU20
  • Mouse_swiss_link： http://www.uniprot.org/uniprot/Q9WU20
  • 特異性： MTHFR Monoclonal Antibody detects endogenous levels of MTHFR protein.
  • 組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 來源： Monoclonal, Mouse
  • 稀釋： WB 1:500 - 1:2000. IHC 1:200 - 1:1000. ELISA: 1:10000.. IF 1:50-200
  • 純化工藝： Affinity purification
  • 儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 說明書： 1
  • Msds： MSDS_Antibody.pdf
  • 其他名稱： MTHFR; Methylenetetrahydrofolate reductase
  • 信號通路： One carbon pool by folate;Methane metabolism;
  • 功能： catalytic activity:5-methyltetrahydrofolate + NAD(P)(+) = 5,10-methylenetetrahydrofolate + NAD(P)H.,cofactor:FAD.,disease:Defects in MTHFR are the cause of methylenetetrahydrofolate reductase deficiency (MTHFRD) [MIM:236250]. MTHFRD is autosomal recessive disorder with a wide range of features including homocysteinuria, homocysteinemia [MIM:603174], developmental delay, severe mental retardation, perinatal death, psychiatric disturbances, and later-onset neurodegenerative disorders.,disease:Defects in MTHFR may be a cause of susceptibility to folate-sensitive neural tube defects (folate-sensitive NTD) [MIM:601634]. The most common NTDs are open spina bifida (myelomeningocele) and anencephaly.,disease:Defects in MTHFR may be a cause of susceptibility to ischemic stroke [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.,enzyme regulation:Allosterically regulated by S-adenosylmethionine.,function:Catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine.,online information:Methylenetetrahydrofolate reductase entry,online information:The Singapore human mutation and polymorphism database,pathway:One-carbon metabolism; tetrahydrofolate pathway.,polymorphism:Genetic variation in MTHFR influences susceptibility to occlusive vascular disease, neural tube defects (NTD), colon cancer and acute leukemia.,similarity:Belongs to the methylenetetrahydrofolate reductase family.,subunit:Homodimer.,
  • 相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
  • 細胞定位： cytosol,synapse,
  • 組織表達： Brain,Liver,Lung,
  • 科研貨號： PLA004943
    • Hunan UPT Biotechnology Co.,Ltd
    Website：www.hyjdss.com Servive hotline :4006916686
    E-mail：service@uptbio.com
    Address：
    Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.
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