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首頁 > 抗體 > 一抗 > 其它 > LKB1 Monoclonal Antibody
LKB1 Monoclonal Antibody
商品貨號(hào)： PLA004914
適 應(yīng) 性： 人,小鼠,猴
WB ELISA FCM
￥600元
規(guī)格：
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MSDS
說明書
商品描述
  • 發(fā)貨日期： 7
  • 基因名稱： STK11
  • 蛋白名稱： Serine/threonine-protein kinase 11
  • Human_gene_id： 6794
  • Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6794
  • Human_swiss_prot_no： Q15831
  • Human_swiss_link： http://www.uniprot.org/uniprotkb/Q15831/entry
  • Mouse_gene_id： 20869
  • Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20869
  • Mouse_swiss_prot_no： Q9WTK7
  • Mouse_swiss_link： http://www.uniprot.org/uniprot/Q9WTK7
  • 特異性： LKB1 Monoclonal Antibody detects endogenous levels of LKB1 protein.
  • 組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 來源： Monoclonal, Mouse
  • 稀釋： WB 1:500 - 1:2000. Flow cytometry: 1:200 - 1:400. ELISA: 1:10000. Not yet tested in other applications.
  • 純化工藝： Affinity purification
  • 儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 說明書： 1
  • Msds： MSDS_Antibody.pdf
  • 其他名稱： STK11; LKB1; PJS; Serine/threonine-protein kinase STK11; Liver kinase B1; LKB1; hLKB1; Renal carcinoma antigen NY-REN-19
  • 信號(hào)通路： Insulin Receptor; mTOR; AMPK
  • 功能： catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium or manganese.,disease:Defects in STK11 are a cause of Peutz-Jeghers syndrome (PJS) [MIM:175200]. PJS is a rare hereditary disease in which there is predisposition to benign and malignant tumors of many organ systems. PJS is an autosomal dominant disorder characterized by melanocytic macules of the lips, multiple gastrointestinal hamartomatous polyps and an increased risk for various neoplasms, including gastrointestinal cancer.,disease:Defects in STK11 have been associated with testicular tumors [MIM:273300]. It includes germ cell tumor (GCT) or testicular germ cell tumor (TGCT).,enzyme regulation:Activated by binding of a complex consisting of CAB39 and STRAD or CAB39 and ALS2CR2.,function:Essential role in G1 cell cycle arrest. Phosphorylates and activates members of the AMPK-related subfamily of protein kinases. Tumor suppressor.,online information:PJS entry,PTM:Phosphorylated by a cAMP-dependent protein kinase.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. LKB1 subfamily.,similarity:Contains 1 protein kinase domain.,subcellular location:Relocates to the cytoplasm when bound to CAB39 and STRAD or CAB39 and ALS2CR2.,subunit:Found in a ternary complex composed of SMAD4, STK11 and STK11IP. Interacts with SMAD4 and STK11IP.,tissue specificity:Ubiquitously expressed. Strongest expression in testis and fetal liver.,
  • 相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
  • 細(xì)胞定位： Nucleus. Cytoplasm. Membrane . Mitochondrion. A small fraction localizes at membranes (By similarity). Relocates to the cytoplasm when bound to STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta). Translocates to the mitochondrion during apoptosis. PTEN promotes cytoplasmic localization. .; [Isoform 2]: Nucleus . Cytoplasm . Predominantly nuclear, but translocates to the cytoplasm in response to metformin or peroxynitrite treatment.
  • 組織表達(dá)： Ubiquitously expressed. Strongest expression in testis and fetal liver.
  • tag： hot
  • 科研貨號(hào)： PLA004914
LKB1 Monoclonal Antibody
Catalog No PLA004914
Product information
  • 發(fā)貨日期： 7
  • 基因名稱： STK11
  • 蛋白名稱： Serine/threonine-protein kinase 11
  • Human_gene_id： 6794
  • Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6794
  • Human_swiss_prot_no： Q15831
  • Human_swiss_link： http://www.uniprot.org/uniprotkb/Q15831/entry
  • Mouse_gene_id： 20869
  • Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20869
  • Mouse_swiss_prot_no： Q9WTK7
  • Mouse_swiss_link： http://www.uniprot.org/uniprot/Q9WTK7
  • 特異性： LKB1 Monoclonal Antibody detects endogenous levels of LKB1 protein.
  • 組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 來源： Monoclonal, Mouse
  • 稀釋： WB 1:500 - 1:2000. Flow cytometry: 1:200 - 1:400. ELISA: 1:10000. Not yet tested in other applications.
  • 純化工藝： Affinity purification
  • 儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 說明書： 1
  • Msds： MSDS_Antibody.pdf
  • 其他名稱： STK11; LKB1; PJS; Serine/threonine-protein kinase STK11; Liver kinase B1; LKB1; hLKB1; Renal carcinoma antigen NY-REN-19
  • 信號(hào)通路： Insulin Receptor; mTOR; AMPK
  • 功能： catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium or manganese.,disease:Defects in STK11 are a cause of Peutz-Jeghers syndrome (PJS) [MIM:175200]. PJS is a rare hereditary disease in which there is predisposition to benign and malignant tumors of many organ systems. PJS is an autosomal dominant disorder characterized by melanocytic macules of the lips, multiple gastrointestinal hamartomatous polyps and an increased risk for various neoplasms, including gastrointestinal cancer.,disease:Defects in STK11 have been associated with testicular tumors [MIM:273300]. It includes germ cell tumor (GCT) or testicular germ cell tumor (TGCT).,enzyme regulation:Activated by binding of a complex consisting of CAB39 and STRAD or CAB39 and ALS2CR2.,function:Essential role in G1 cell cycle arrest. Phosphorylates and activates members of the AMPK-related subfamily of protein kinases. Tumor suppressor.,online information:PJS entry,PTM:Phosphorylated by a cAMP-dependent protein kinase.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. LKB1 subfamily.,similarity:Contains 1 protein kinase domain.,subcellular location:Relocates to the cytoplasm when bound to CAB39 and STRAD or CAB39 and ALS2CR2.,subunit:Found in a ternary complex composed of SMAD4, STK11 and STK11IP. Interacts with SMAD4 and STK11IP.,tissue specificity:Ubiquitously expressed. Strongest expression in testis and fetal liver.,
  • 相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
  • 細(xì)胞定位： Nucleus. Cytoplasm. Membrane . Mitochondrion. A small fraction localizes at membranes (By similarity). Relocates to the cytoplasm when bound to STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta). Translocates to the mitochondrion during apoptosis. PTEN promotes cytoplasmic localization. .; [Isoform 2]: Nucleus . Cytoplasm . Predominantly nuclear, but translocates to the cytoplasm in response to metformin or peroxynitrite treatment.
  • 組織表達(dá)： Ubiquitously expressed. Strongest expression in testis and fetal liver.
  • tag： hot
  • 科研貨號(hào)： PLA004914
    • Hunan UPT Biotechnology Co.,Ltd
    Website：www.hyjdss.com Servive hotline :4006916686
    E-mail：service@uptbio.com
    Address：
    Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.
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