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LEDGF Monoclonal Antibody
商品貨號： PLA004910
適 應(yīng) 性： 人,大鼠,猴
WB IHC IF ELISA
￥600元
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MSDS
說明書
商品描述
  • 發(fā)貨日期： 7
  • 基因名稱： PSIP1
  • 蛋白名稱： PC4 and SFRS1-interacting protein
  • Human_gene_id： 11168
  • Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11168
  • Human_swiss_prot_no： O75475
  • Human_swiss_link： http://www.uniprot.org/uniprotkb/O75475/entry
  • Mouse_swiss_prot_no： Q99JF8
  • Mouse_swiss_link： http://www.uniprot.org/uniprot/Q99JF8
  • Rat_gene_id： 313323
  • Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=313323
  • Rat_swiss_prot_no： Q812D1
  • Rat_swiss_link： http://www.uniprot.org/uniprot/Q812D1
  • 特異性： LEDGF Monoclonal Antibody detects endogenous levels of LEDGF protein.
  • 組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 來源： Monoclonal, Mouse
  • 稀釋： WB 1:500 - 1:2000. IHC 1:200 - 1:1000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
  • 純化工藝： Affinity purification
  • 儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 說明書： 1
  • Msds： MSDS_Antibody.pdf
  • 其他名稱： PSIP1; DFS70; LEDGF; PSIP2; PC4 and SFRS1-interacting protein; CLL-associated antigen KW-7; Dense fine speckles 70 kDa protein; DFS 70; Lens epithelium-derived growth factor; Transcriptional coactivator p75/p52
  • 功能： disease:A chromosomal aberration involving PSIP1 is associated with pediatric acute myeloid leukemia (AML) with intermediate characteristics between M2-M3 French-American-British (FAB) subtypes. Translocation t(9;11)(p22;p15) with NUP98. The chimeric transcript is an in-frame fusion of NUP98 exon 8 to PSIP1/LEDGF exon 4.,domain:Residues 340-417 are necessary and sufficient for the interaction with HIV-1 IN (IBD domain).,function:Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the HDGF family.,similarity:Contains 1 PWWP domain.,subcellular location:Remains chromatin-associated throughout the cell cycle.,subunit:Monomer. Interacts with IFRD1/PC4. Isoform 2 interacts with SFRS1. Isoform 1 interacts with lentiviral integrase and acts as a chromatin tethering factor to the chromosomal DNA. Isoform 1 interacts in particular with the human HIV-1 integrase protein (HIV-1 IN), determining its nuclear localization, its tight association with chromatin and its protection from the proteasome. Isoform 1 interacts also with HIV-2 IN. Isoform 2 does not interact with HIV-1 IN.,tissue specificity:Widely expressed. Expressed at high level in the thymus. Expressed in fetal and adult brain. Expressed in neurons, but not astrocytes. Markedly elevated in fetal as compared to adult brain. In the adult brain, expressed in the subventricular zone (SVZ), in hippocampus, and undetectable elsewhere. In the fetal brain, expressed in the germinal neuroepithelium and cortical plate regions.,
  • 相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
  • 細胞定位： Nucleus . Remains chromatin-associated throughout the cell cycle.
  • 組織表達： Widely expressed. Expressed at high level in the thymus. Expressed in fetal and adult brain. Expressed in neurons, but not astrocytes. Markedly elevated in fetal as compared to adult brain. In the adult brain, expressed in the subventricular zone (SVZ), in hippocampus, and undetectable elsewhere. In the fetal brain, expressed in the germinal neuroepithelium and cortical plate regions.
  • 科研貨號： PLA004910
LEDGF Monoclonal Antibody
Catalog No PLA004910
Product information
  • 發(fā)貨日期： 7
  • 基因名稱： PSIP1
  • 蛋白名稱： PC4 and SFRS1-interacting protein
  • Human_gene_id： 11168
  • Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11168
  • Human_swiss_prot_no： O75475
  • Human_swiss_link： http://www.uniprot.org/uniprotkb/O75475/entry
  • Mouse_swiss_prot_no： Q99JF8
  • Mouse_swiss_link： http://www.uniprot.org/uniprot/Q99JF8
  • Rat_gene_id： 313323
  • Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=313323
  • Rat_swiss_prot_no： Q812D1
  • Rat_swiss_link： http://www.uniprot.org/uniprot/Q812D1
  • 特異性： LEDGF Monoclonal Antibody detects endogenous levels of LEDGF protein.
  • 組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 來源： Monoclonal, Mouse
  • 稀釋： WB 1:500 - 1:2000. IHC 1:200 - 1:1000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
  • 純化工藝： Affinity purification
  • 儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 說明書： 1
  • Msds： MSDS_Antibody.pdf
  • 其他名稱： PSIP1; DFS70; LEDGF; PSIP2; PC4 and SFRS1-interacting protein; CLL-associated antigen KW-7; Dense fine speckles 70 kDa protein; DFS 70; Lens epithelium-derived growth factor; Transcriptional coactivator p75/p52
  • 功能： disease:A chromosomal aberration involving PSIP1 is associated with pediatric acute myeloid leukemia (AML) with intermediate characteristics between M2-M3 French-American-British (FAB) subtypes. Translocation t(9;11)(p22;p15) with NUP98. The chimeric transcript is an in-frame fusion of NUP98 exon 8 to PSIP1/LEDGF exon 4.,domain:Residues 340-417 are necessary and sufficient for the interaction with HIV-1 IN (IBD domain).,function:Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the HDGF family.,similarity:Contains 1 PWWP domain.,subcellular location:Remains chromatin-associated throughout the cell cycle.,subunit:Monomer. Interacts with IFRD1/PC4. Isoform 2 interacts with SFRS1. Isoform 1 interacts with lentiviral integrase and acts as a chromatin tethering factor to the chromosomal DNA. Isoform 1 interacts in particular with the human HIV-1 integrase protein (HIV-1 IN), determining its nuclear localization, its tight association with chromatin and its protection from the proteasome. Isoform 1 interacts also with HIV-2 IN. Isoform 2 does not interact with HIV-1 IN.,tissue specificity:Widely expressed. Expressed at high level in the thymus. Expressed in fetal and adult brain. Expressed in neurons, but not astrocytes. Markedly elevated in fetal as compared to adult brain. In the adult brain, expressed in the subventricular zone (SVZ), in hippocampus, and undetectable elsewhere. In the fetal brain, expressed in the germinal neuroepithelium and cortical plate regions.,
  • 相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
  • 細胞定位： Nucleus . Remains chromatin-associated throughout the cell cycle.
  • 組織表達： Widely expressed. Expressed at high level in the thymus. Expressed in fetal and adult brain. Expressed in neurons, but not astrocytes. Markedly elevated in fetal as compared to adult brain. In the adult brain, expressed in the subventricular zone (SVZ), in hippocampus, and undetectable elsewhere. In the fetal brain, expressed in the germinal neuroepithelium and cortical plate regions.
  • 科研貨號： PLA004910
    • Hunan UPT Biotechnology Co.,Ltd
    Website：www.hyjdss.com Servive hotline :4006916686
    E-mail：service@uptbio.com
    Address：
    Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.
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