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首頁(yè) > 抗體 > 一抗 > 其它 > HDAC3 Monoclonal Antibody
HDAC3 Monoclonal Antibody
商品貨號(hào)： PLA004847
適 應(yīng) 性： 人
WB IF ELISA
￥600元
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MSDS
說(shuō)明書(shū)
商品描述
  • 發(fā)貨日期： 7
  • 基因名稱： HDAC3
  • 蛋白名稱： Histone deacetylase 3
  • Human_gene_id： 8841
  • Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8841
  • Human_swiss_prot_no： O15379
  • Human_swiss_link： http://www.uniprot.org/uniprotkb/O15379/entry
  • Mouse_swiss_prot_no： O88895
  • Mouse_swiss_link： http://www.uniprot.org/uniprot/O88895
  • 特異性： HDAC3 Monoclonal Antibody detects endogenous levels of HDAC3 protein.
  • 組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 來(lái)源： Monoclonal, Mouse
  • 稀釋： WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
  • 純化工藝： Affinity purification
  • 儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 說(shuō)明書(shū)： 1
  • Msds： MSDS_Antibody.pdf
  • 其他名稱： HDAC3; Histone deacetylase 3; HD3; RPD3-2; SMAP45
  • 信號(hào)通路： Protein_Acetylation
  • 功能： catalytic activity:Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.,function:Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor.,PTM:Sumoylated in vitro.,similarity:Belongs to the histone deacetylase family. Type 1 subfamily.,subunit:Interacts with HDAC7 and HDAC9. Forms a heterologous complex at least with YY1. Interacts with DAXX, HDAC10 and DACH1. Found in a complex with NCOR1 and NCOR2. Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2. Interacts with BCOR, MJD2A/JHDM3A, NRIP1, PRDM6 and SRY. Interacts with BTBD14B. Interacts with GLIS2 (By similarity). Interacts with CBFA2T3.,tissue specificity:Widely expressed.,
  • 相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
  • 細(xì)胞定位： Nucleus . Cytoplasm . Cytoplasm, cytosol . Colocalizes with XBP1 and AKT1 in the cytoplasm (PubMed:25190803). Predominantly expressed in the nucleus in the presence of CCAR2 (PubMed:21030595). .
  • 組織表達(dá)： Widely expressed.
  • 科研貨號(hào)： PLA004847
HDAC3 Monoclonal Antibody
Catalog No PLA004847
Product information
  • 發(fā)貨日期： 7
  • 基因名稱： HDAC3
  • 蛋白名稱： Histone deacetylase 3
  • Human_gene_id： 8841
  • Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8841
  • Human_swiss_prot_no： O15379
  • Human_swiss_link： http://www.uniprot.org/uniprotkb/O15379/entry
  • Mouse_swiss_prot_no： O88895
  • Mouse_swiss_link： http://www.uniprot.org/uniprot/O88895
  • 特異性： HDAC3 Monoclonal Antibody detects endogenous levels of HDAC3 protein.
  • 組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 來(lái)源： Monoclonal, Mouse
  • 稀釋： WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
  • 純化工藝： Affinity purification
  • 儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 說(shuō)明書(shū)： 1
  • Msds： MSDS_Antibody.pdf
  • 其他名稱： HDAC3; Histone deacetylase 3; HD3; RPD3-2; SMAP45
  • 信號(hào)通路： Protein_Acetylation
  • 功能： catalytic activity:Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.,function:Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor.,PTM:Sumoylated in vitro.,similarity:Belongs to the histone deacetylase family. Type 1 subfamily.,subunit:Interacts with HDAC7 and HDAC9. Forms a heterologous complex at least with YY1. Interacts with DAXX, HDAC10 and DACH1. Found in a complex with NCOR1 and NCOR2. Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2. Interacts with BCOR, MJD2A/JHDM3A, NRIP1, PRDM6 and SRY. Interacts with BTBD14B. Interacts with GLIS2 (By similarity). Interacts with CBFA2T3.,tissue specificity:Widely expressed.,
  • 相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
  • 細(xì)胞定位： Nucleus . Cytoplasm . Cytoplasm, cytosol . Colocalizes with XBP1 and AKT1 in the cytoplasm (PubMed:25190803). Predominantly expressed in the nucleus in the presence of CCAR2 (PubMed:21030595). .
  • 組織表達(dá)： Widely expressed.
  • 科研貨號(hào)： PLA004847
    • Hunan UPT Biotechnology Co.,Ltd
    Website：www.hyjdss.com Servive hotline :4006916686
    E-mail：service@uptbio.com
    Address：
    Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.
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