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GATA-1 Monoclonal Antibody
商品貨號(hào)： PLA004823
適 應(yīng) 性： 人
WB IHC IF ELISA
￥600元
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MSDS
說(shuō)明書(shū)
商品描述
  • 發(fā)貨日期： 7
  • 基因名稱： GATA1
  • 蛋白名稱： Erythroid transcription factor
  • Human_gene_id： 2623
  • Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2623
  • Human_swiss_prot_no： P15976
  • Human_swiss_link： http://www.uniprot.org/uniprotkb/P15976/entry
  • Mouse_swiss_prot_no： P17679
  • Mouse_swiss_link： http://www.uniprot.org/uniprot/P17679
  • 特異性： GATA-1 Monoclonal Antibody detects endogenous levels of GATA-1 protein.
  • 組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 來(lái)源： Monoclonal, Mouse
  • 稀釋： WB 1:500 - 1:2000. IHC 1:200 - 1:1000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
  • 純化工藝： Affinity purification
  • 儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 說(shuō)明書(shū)： 1
  • Msds： MSDS_Antibody.pdf
  • 其他名稱： GATA1; ERYF1; GF1; Erythroid transcription factor; Eryf1; GATA-binding factor 1; GATA-1; GF-1; NF-E1 DNA-binding protein
  • 信號(hào)通路： Protein_Acetylation
  • 功能： disease:Defects in GATA1 are the cause of X-linked dyserythropoietic anemia and thrombocytopenia (XDAT) [MIM:300367]. XDAT is a disorder characterized by erythrocytes with abnormal size and shape, and paucity of platelets in peripheral blood. The bone marrow contains abundant and abnormally small megakaryocytes.,disease:Defects in GATA1 are the cause of X-linked thrombocytopenia with beta-thalassemia (XLTT) [MIM:314050]; also called thrombocytopenia, platelet dysfunction, hemolysis, and imbalanced globin synthesis. The disease consists of an unusual form of thrombocytopenia with beta-thalassemia. Patients have splenomegaly and petechiae, moderate thrombocytopenia, prolonged bleeding time due to platelet dysfunction, reticulocytosis and unbalanced (hemo)globin chain synthesis resembling that of beta-thalassemia minor.,domain:The two fingers are functionally distinct and cooperate to achieve specific, stable DNA binding. The first finger is necessary only for full specificity and stability of binding, whereas the second one is required for binding.,function:Transcriptional activator which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence [AT]GATA[AG] within regulatory regions of globin genes and of other genes expressed in erythroid cells.,PTM:Highly phosphorylated on serine residues. Phosphorylation on Ser-310 is enhanced on erythroid differentiation. Phosphorylation on Ser-142 promotes sumoylation on Lys-137.,PTM:Sumoylation on Lys-137 is enhanced by phosphorylation on Ser-142 and by interaction with PIAS4. Sumoylation by SUMO1 has no effect on transcriptional activity.,similarity:Contains 2 GATA-type zinc fingers.,subunit:Interacts (via the N-terminal zinc finger) with ZFPM1. Interacts with GFI1B. Interacts with PIAS4; the interaction enhances sumoylation and represses the transactivational activity in a sumoylation-independent manner.,tissue specificity:Erythrocytes.,
  • 相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
  • 細(xì)胞定位： Nucleus.
  • 組織表達(dá)： Erythrocytes.
  • 科研貨號(hào)： PLA004823
GATA-1 Monoclonal Antibody
Catalog No PLA004823
Product information
  • 發(fā)貨日期： 7
  • 基因名稱： GATA1
  • 蛋白名稱： Erythroid transcription factor
  • Human_gene_id： 2623
  • Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2623
  • Human_swiss_prot_no： P15976
  • Human_swiss_link： http://www.uniprot.org/uniprotkb/P15976/entry
  • Mouse_swiss_prot_no： P17679
  • Mouse_swiss_link： http://www.uniprot.org/uniprot/P17679
  • 特異性： GATA-1 Monoclonal Antibody detects endogenous levels of GATA-1 protein.
  • 組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 來(lái)源： Monoclonal, Mouse
  • 稀釋： WB 1:500 - 1:2000. IHC 1:200 - 1:1000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
  • 純化工藝： Affinity purification
  • 儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 說(shuō)明書(shū)： 1
  • Msds： MSDS_Antibody.pdf
  • 其他名稱： GATA1; ERYF1; GF1; Erythroid transcription factor; Eryf1; GATA-binding factor 1; GATA-1; GF-1; NF-E1 DNA-binding protein
  • 信號(hào)通路： Protein_Acetylation
  • 功能： disease:Defects in GATA1 are the cause of X-linked dyserythropoietic anemia and thrombocytopenia (XDAT) [MIM:300367]. XDAT is a disorder characterized by erythrocytes with abnormal size and shape, and paucity of platelets in peripheral blood. The bone marrow contains abundant and abnormally small megakaryocytes.,disease:Defects in GATA1 are the cause of X-linked thrombocytopenia with beta-thalassemia (XLTT) [MIM:314050]; also called thrombocytopenia, platelet dysfunction, hemolysis, and imbalanced globin synthesis. The disease consists of an unusual form of thrombocytopenia with beta-thalassemia. Patients have splenomegaly and petechiae, moderate thrombocytopenia, prolonged bleeding time due to platelet dysfunction, reticulocytosis and unbalanced (hemo)globin chain synthesis resembling that of beta-thalassemia minor.,domain:The two fingers are functionally distinct and cooperate to achieve specific, stable DNA binding. The first finger is necessary only for full specificity and stability of binding, whereas the second one is required for binding.,function:Transcriptional activator which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence [AT]GATA[AG] within regulatory regions of globin genes and of other genes expressed in erythroid cells.,PTM:Highly phosphorylated on serine residues. Phosphorylation on Ser-310 is enhanced on erythroid differentiation. Phosphorylation on Ser-142 promotes sumoylation on Lys-137.,PTM:Sumoylation on Lys-137 is enhanced by phosphorylation on Ser-142 and by interaction with PIAS4. Sumoylation by SUMO1 has no effect on transcriptional activity.,similarity:Contains 2 GATA-type zinc fingers.,subunit:Interacts (via the N-terminal zinc finger) with ZFPM1. Interacts with GFI1B. Interacts with PIAS4; the interaction enhances sumoylation and represses the transactivational activity in a sumoylation-independent manner.,tissue specificity:Erythrocytes.,
  • 相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
  • 細(xì)胞定位： Nucleus.
  • 組織表達(dá)： Erythrocytes.
  • 科研貨號(hào)： PLA004823
    • Hunan UPT Biotechnology Co.,Ltd
    Website：www.hyjdss.com Servive hotline :4006916686
    E-mail：service@uptbio.com
    Address：
    Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.
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